Innovative DNA and Protein Products
Protein Potential's Research and Development Group focuses on producing intellectual property and recombinant bacteria, recombinant protein, and DNA products. Protein Potential's primary focus is on development of vaccines to protect against enteric diseases including shigellosis, diarrhea caused by ETEC, and typhoid fever and bioterrorism agents using its platform technology of recombinant, acid-stabilized Ty21a. Protein Potential is also developing subunit vaccines for Plasmodium falciparum and Plasmodium vivax malaria.
Protein Potential's Products and Services Group provides pharmaceutical and biotechnology companies, and government and academic institutions with high quality, purified, recombinant proteins and DNA plasmids for research and development. Protein Potential also provides process development, documentation, and technological know-how to transition therapeutic, vaccine, and diagnostic proteins and DNA plasmids to large-scale cGMP manufacturing.
Protein Expression Services
We have extensive experience with DNA plasmids and a variety of systems used for the production of recombinant proteins. Our services are custom-tailored to meet the needs of industry, academic and government researchers. Each project is uniquely designed depending on the clients needs, resources and ability to collaborate. We can assist one or more steps in the process or serve as the R&D team.
Our Services Encompass:
Gene cloning and vector construction
Clone screening and selection
Strain development and expression optimization
Strain improvement and expression enhancement
Cell bank preparation and characterization
Bioreactor fermentation production and optimization
Purification process development
Analytical assay development
Product characterization for identity, purity and potency
Formulation and stability analysis
Bench- and up to pilot-scale production
Technology transfer to cGMP facilities
Oversight at cGMP site during manufacture
Preparation of CMC documents and consultation for IND filing